High Potency Protease (60)

MSRP: $50.05


Protease enzyme supplement for breaking down proteins and enhancing immunity. High-Potency Protease. Provides supplemental protease enzymes that break down proteins into smaller proteins and amino acids, maximizing digestion. [Digestive, Immune]

Product Description


  • Enhances the digestion of proteins.
  • Supports the immune and respiratory systems(when taken between meals).
  • Increases the absorption of nutrients.
  • Helps promote joint health and function.
  • Supports arterial health.

High – Potency Protease [Digestive, Immune] provides supplemental protease enzymes that break down proteins into smaller proteins and amino acids, maximizing digestion. They are found in the stomach and in the pancreatic and intestinal juices.

As we grow older, our bodies produce fewer enzymes. When a deficiency of protease enzyme exists, undigested proteins can pass through the intestinal tract and remain undigested. These have been linked to a variety of unsavory health concerns. Protease breaks down food proteins into smaller proteins and amino acids, maximizing digestion.

This product also supports the immune system by activating macrophages and natural killer cells. Protease also increases the flexibility of red blood cells, improving blood flow.

NSP’s formula provides a full spectrum of plant-derived trace minerals, which help activate enzymes.

Each capsule of NSP High Potency Protease delivers 180,000 HUTs (Hemoglobin units, tyrosine basis) with a full spectrum of trace minerals.

Enjoy the same benefits of three Protease Plus capsules in one capsule of High-Potency Protease.

Recommended Usage:

Take 1-3 capsules between meals up to three times daily.

SIZE: 60 capsules

Supplement Facts
Serving Size: 1
Servings Per Container: 60
Amount Per: 1 Capsule % Daily Value *
Protease (180,000 HUT)400 mg *
*Daily Value Not Established.

Other Ingredients: Trace Mineral Concentrate, Gelatin, And Water.

High Potency Protease

High Potency Protease is a concentrated source of protease enzymes, which have been shown to improve protein digestion, reduce inflammation and speed the healing of wounds, inhibit the formation of blood clots, protect against intestinal parasitic infection and the overgrowth of yeast, and support immune function. High Potency Protease also contains bentonite, a concentrated source of minerals and trace nutrients—all enzyme activities involve minerals.1,2

Enzymes are essential nutrients that initiate virtually all of the chemical reactions occurring within the body. Enzymes also aid in the elimination of toxins, including potentially harmful allergens and environmental pollutants. Unless obtained in the diet (from raw fruits and vegetables or dietary supplements), the constant demands on the body to manufacture enzymes can cause enzyme deficiency—a common problem that can lead to digestive dysfunction, cardiovascular disease, obesity, cancer and other illnesses. For example, enzyme deficiency is believed to be part of the mechanism that enables cholesterol deposits to accumulate along the inside of arterial walls, ultimately manifesting in heart disease.1-4

Incomplete digestion can be a major contributor to the development of numerous disease conditions. Approximately 58% of the population is believed to suffer from some type of digestive disorder. Not only can digestive dysfunction lead to nutritional deficiency and upset of healthy bowel flora, but in addition, incompletely digested macromolecules can be absorbed into the systemic circulation (the bloodstream). This can lead to a variety of immune complex diseases and is theorized to play an integral role in the etiology (origin) of food allergies. Antigenic (capable of producing an immune response) macromolecules can trigger the body’s defenses against exposure to what is perceived as foreign protein, thus producing symptoms of allergy. Furthermore, incompletely digested protein creates a favorable environment for "unfriendly" colonic bacteria, many of which create toxic substances that are absorbed by the body.2,4-6

Protease enzymes—also referred to as proteolytic enzymes—break down proteins into single amino acids and are capable of breaking down 300 grams of protein per hour. However, protease supplementation is beneficial for more than just improving digestion. Numerous human studies show that supplemental proteases given orally are absorbed intact into the bloodstream where they are able to act systemically (affecting the whole body), providing analgesic (pain-relieving), anti-inflammatory and edema-reducing activities—proteolytic enzymes are important regulators and modulators of the inflammatory response. Thus, protease enzymes have been used to treat acute inflammatory conditions such as sports injuries, surgery and wounds, as well as reduce pain in various rheumatic diseases, including periarthritis of the shoulder and osteoarthritis of the knee. Proteolytic enzymes have even been shown to reduce pain, as well as significantly reduce the need for analgesics in women undergoing episiotomy—a surgical incision into the perineum and vagina to prevent traumatic tearing during childbirth. In addition, proteolytic enzymes have been used therapeutically to reduce and eliminate food allergies; fight cancer and infections, including viral infections such as shingles (Herpes zoster) and AIDS; and combat auto-immune diseases such as rheumatoid arthritis, multiple sclerosis and scleroderma. Plus, research shows that proteases are largely responsible for keeping the small intestine clear of parasites, including bacteria, intestinal worms, protozoa and yeast. Thus, a lack of protease can greatly increase the chances of intestinal infection and the overgrowth of the yeast Candida albicans. Furthermore, proteases stimulate phagocytosis—the ingestion of waste material, harmful microorganisms or other foreign bodies by specialized cells—within the immune system and accelerate the elimination of cell debris, fibrin (insoluble protein that forms the essential portion of a blood clot) and toxins by way of the lymphatic system and blood vessels.1,2,5,7-16

In addition, protease is an important component in preventing tissue damage during inflammation and the production of fibrin clots. Protease increases the breakdown of fibrin—a process known as fibrinolysis. Fibrin promotes inflammation by forming a wall around the area of inflammation, blocking blood and lymph vessels and causing swelling. Increased fibrin formation is also believed to be associated with production of cholesterol and fatty material, which inhibit circulation and contribute to heart disease. In addition, fibrin can cause blood clots to develop, which, if they become dislodged, can cause strokes or heart attack. Therefore, protease enzymes are often used therapeutically to treat thrombophlebitis—a disease where blood clots develop in veins, the veins become inflamed, and the clots dislodge, causing a stroke or heart attack.1,5,8,9,11,16

Protease's ability to dissolve fibrin is also beneficial in the treatment of cancer. Cancer cells are covered with a thick "coat" of adhesive fibrin (referred to as "fibrin masking"), thus making the cancerous cells no longer recognizable by the body’s immune cells. In response, protease enzymes effectively dissolve the fibrin coating of cancer cells, exposing their antigens to destruction by macrophages and the entire immune system. European oncologists have, for many years, included enzyme supplements as a natural, non-toxic adjuvant therapy against cancer; while nearly all of the leading alternative cancer specialists treating Americans prescribe enzymes as either primary or adjuvant cancer therapies. A review of clinical trials of systemic enzyme therapy in oncology—the study of diseases that cause cancer—has shown that enzyme therapy can reduce the adverse effects caused by radiotherapy and chemotherapy, and there is also evidence that, in some types of tumors, survival may be extended. Research also indicates the importance of oral administration of proteolytic enzymes in the supporting treatment of malignant processes in multiple myeloma.1,4,5,10,17-21

For example, a 2-year pilot study of 11 patients with inoperable pancreatic adenocarcinoma (pancreatic cancer) led to significantly increased survival using large doses of proteolytic enzymes, combined with an aggressive nutritional therapy. The National Cancer Data Base reports that survival rates for all stages of pancreatic cancer are 25% survival at 1 year and only 10% survival at 2 years. However, 9 patients (81%) in the pilot study survived 1 year and 5 patients (45%) survived 2 years. Additionally, 4 patients were still living at 3 years.1,22

In addition, a controlled, clinical trial involving 649 breast cancer patients was conducted to determine the effects of treatment with an oral enzyme preparation given postoperatively in conjunction with antineoplastics—substances that prevent the development of abnormal tissue growth. The results showed that the typical disease- and therapy-associated signs and symptoms in patients receiving oral enzymes were significantly less—75% of the test group versus 55% of the control group experienced “no signs and symptoms.” A clear reduction in the side effects of radiotherapy and chemotherapy was also documented in 74% of the test group compared to 55% of the control group. In addition, analysis of survival, recurrence, and metastasis demonstrated a reduced number of events in the test group, with evidence of a beneficial influence of oral enzymes on the length of time to event. Researchers concluded that complementary treatment of breast cancer patients with oral enzymes improved the quality of life by reducing signs and symptoms of the disease and the side effects of adjuvant antineoplastic therapies. This study also provided evidence that patients may gain benefit from oral enzymes by prolonging the time to event for cancer recurrence, metastasis and survival. Similar results were also found in a study involving patients with colorectal cancer.23,24

Furthermore, protease enzymes are essential for dissolving and preventing the deposit of immune complexes in body tissues. Immune complexes are inflammatory byproducts of antibody attacks on antigens that are normally eliminated from the bloodstream by macrophages. Immune complexes that continue to circulate can be deposited in tissues where they can cause significant local tissue damage. Diseases such as AIDS, ankylosing spondylitis (arthritis of the spine), Crohn's disease, lupus erythematosus, multiple sclerosis, pulmonary fibrosis, rheumatoid arthritis, scleroderma, and ulcerative colitis are associated with high levels of circulating immune complexes. Fortunately, both experimental and clinical studies show that protease preparations are extremely effective in decreasing levels of circulating immune complexes and activating macrophages to break up and eliminate them. Clinical improvements have been shown to correspond with reductions in immune complex levels.1,5,9,14,25,26

Each capsule of NSP's High Potency Protease delivers 180,000 HUT's (Hemoglobin units, tyrosine basis) of protease. Each capsule of High Potency Protease provides the same benefits as three Protease Plus capsules.


1Cichoke DC, A. Enzymes & Enzyme Therapy, 2nd Ed. Los Angeles, CA: Keats, 2000.

2Balch MD, J. & Balch CNC, P. Prescription for Nutritional Healing, 3rd ed. NY, NY: Avery, 2000.

3Dunne, L. Nutrition Almanac, 3rd edition. NY, NY: McGraw-Hill, 1990.

4Bitomsky, M. “Digestive Enzymes: The Missing Link.” Life Extension Magazine; 1999, 5(4).

5Pizzorno, J.E. & Murray, M.T. A Textbook of Natural Medicine, 2nd ed. Seattle, WA: Bastyr University, 1994.

63Lininger DC, S., et al. The Natural Pharmacy, 2nd ed. Rocklin, CA: Prima Health, 1999.

7Cichoke DC, A. The Complete Book of Enzyme Therapy. Garden City Park, NY: Avery, 1999.

8Wright MD, J. Dr. Wright’s Guide to Healing with Nutrition. Emmaus, PA: Rodale Press, 1984.

9Murray ND, M. Encyclopedia of Nutritional Supplements. Rocklin, CA: Prima Publishing, 1996.

10“Leading European Oncologist Discusses Systemic Oral Enzyme Therapy & Cancer.” The Doctor’s Prescription For Healthy Living; 2000, 4(4).

11Cichoke DC, A. “Enzymes Can Hasten Pain Relief.” Nutrition Science News; February 2001.

12“Supplemental Enzymes.” PDRhealth, 2003. <http://www.pdrhealth.com/drug_info>. Accessed December 2003.

13Klein, G. & Kullich, W. [Reducing pain by oral enzyme therapy in rheumatic diseases]. Wiener Medizinische Wochenschrift; 1999, 149(21-22):577-580.

14Solorzano del Rio PhD, H.E. “Systemic Enzyme Therapy.” The Arthritis Trust of America; 1994. <http://www.arthritistrust.org/downloads/publications/pub070.pdf>. Accessed Dec. 2003.

15Roberts, A.D. & Hart, D.M. “Polyglycolic acid and catgut sutures, with and without oral proteolytic enzymes, in the healing of episiotomies.” British Journal of Obstetrics and Gynaecology; 1983, 90(7):650-653.

16Babal CN, K. “Hot Stock.” Nutrition Science News; January 2000.

17“How Systemic Oral Enzymes Inhibit Cancer Spread.” The Doctor’s Prescription For Healthy Living; 2000, 4(5).

18Desser, L., et. al. “Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood.” Cancer Chemotherapy and Pharmacology; 2001, 47 Suppl:S10-15.

19Kaul, R., et. al. “The role of Wobe-Mugos in reducing acute sequele of radiation in head and neck cancers—a clinical phase-III randomized trial.” Indian Journal of Cancer; 1999, 36(2-4):141-148.

20Leipner, J. & Saller, R. “Systemic enzyme therapy in oncology: effect and mode of action.” Drugs; 2000, 59(4):769-780.

21Sakalova, A., et. al. [Density of adhesive proteins after oral administration of proteolytic enzymes in multiple myeloma]. Vnitrni Lekarstvi; 1995, 41(12):822-826.

22Gonzalez, N.J. & Isaacs, L.L. “Evaluation of pancreatic proteolytic enzyme treatment of adenocarcinoma of the pancreas, with nutrition and detoxification support.” Nutrition and Cancer; 1999, 33(2): 117-124.

23Beuth, J., et. al. “Impact of complementary oral enzyme application on the postoperative treatment results of breast cancer patients--results of an epidemiological multicentre retrolective cohort study.” Cancer Chemotherapy and Pharmacology; 2001, 47 Suppl:S45-54.

24Popiela, T., et. al. “Influence of a complementary treatment with oral enzymes on patients with colorectal cancers--an epidemiological retrolective cohort study.” Cancer Chemotherapy and Pharmacology; 2001, 47 Suppl:S55-63.

25Cichoke DC, A. “Enzyme Therapy for MS Patients.” Nutrition Science News, May 1999.

26Steffen, C. & Menzel, J. [Enzyme breakdown of immune complexes]. Zeitschrift fur Rheumatologie; 1983, 42(5):249-255.

Additional Information


60 capsules



Body System:

Digestive, Immune



Stock Number:


High Potency Protease

Don’t Let Proteins Get the Best of You

As we grow older, our bodies produce fewer enzymes. Enzymes that break down proteins are especially critical to good health because undigested and foreign proteins can impact your overall health. Protease is an important enzyme that helps digest proteins. Supplemental protease between meals helps break down proteins associated with joint structure and function and arterial health. Protease also supports immunity.


  • Enhances the digestion of proteins.
  • Supports the immune and respiratory systems (when taken between meals).
  • Increases the absorption of nutrients.
  • Helps promote joint health and function.
  • Supports arterial health.


Taken with meals, High Potency Protease helps digest high-protein foods. Taken between meals, it acts systemically to break down foreign proteins associated with mucus production and arterial health. High Potency Protease also supports immunity by activating the body’s immune defenses.


NSP High Potency Protease delivers 180,000 HUTs of protease combined with trace minerals to activate enzymes, improving their efficiency. This is a blend of plant-sourced protease enzymes that help digest proteins at various pH levels (3.0, 4.5 and 6.0).


Each capsule of High Potency Protease contains 180,000 HUTs of protease 3.0,4.5 and 6.0 (a blend of three different proteases) plus trace minerals.


Take 1 capsule up to three times daily between meals.

Protease enzyme supplements for breaking down proteins and enhancing immunity

If you removed all of the water from the body, the remaining mass would consist mostly of protein. Proteins not only form much of the basic structure of the body, they are also involved in regulating its function. For example, neurotransmitters, enzymes and many hormones are composed of protein.

When we eat protein, however, the body has to break it down into its component partsamino acids. This is done by means of hydrochloric acid and proteolytic enzymes. Proteases are plant-based proteolytic enzymes that help break proteins down into smaller proteins and amino acids. They can be of great benefit to people who have difficulty digesting proteins, but they have even broader therapeutic applications.

Protease enzymes have proven helpful for a wide variety of health problems. For instance, taking protease between meals can help to get rid of parasites because it literally digests them. Cancer cells surround themselves with a protein coat that interferes with the ability of the immune system to destroy them. So, a popular addition to natural protocols for cancer is protease enzymes between meals.

Protease enzymes are often beneficial in autoimmune disorders, including fibromyalgia and lupus. Breaking down foreign proteins in the system seems to improve and regulate immune function. Protease enzymes may even help the immune system fight infection more effectively.

Increasing your protease enzymes may be helpful for a variety of intestinal disorders. Protease enzymes can help break down the protein gluten, found in grains like wheat, which causes an allergic reaction in Celiac disease. It has also helped other types of inflammatory bowel disorders.

Protease enzymes can also be beneficial in preventing heart disease. They help to keep the blood from becoming too thick, thereby helping to prevent the blood clots involved in heart attack and stroke. They do this without decreasing the ability of the blood to clot normally.

Here are some beneficial products for supplementing protease enzymes.

Protease Plus

Each capsule of Protease Plus contains 60,000 HUTs of protease. An HUT is a unit of measurement used to indicate the amount of protein protease enzymes can digest. These protease enzymes are in a base of beet root fiber and plant-source trace minerals. Beet root contains a small amount of betaine HCl (hydrochloric acid) which aids in protein digestion. Trace minerals help to catalyze enzyme activity.

High Potency Protease

Each capsule of High Potency Protease contains 180,000 HUTs of protease, making it equivalent in potency to three Protease Plus capsules. The formula also includes plant-derived trace minerals and beet root.

Small Intestine Detox

Small intestine detox contains pepsin, a proteolytic enzyme, mixed with marshmallow. The mucilage in the marshmallow helps coat the pepsin and deliver it intact into the small intestine where it breaks down previously undigested protein matter. This helps to cleanse the small intestines and improve nutrient absorption.

Suggested Use

Take 1 capsule of Protease Plus with meals to aid in the digestion of food. For heavy protein meals use 1 capsule of High Potency Protease. Both formulas are taken between meals to help with parasites, cancer and immune disorders. Consult a skilled nutritionist or health practitioner for details. For Small Intestine Detox take 1-2 capsules two to three times daily. For best results as a detoxifier, take at least 30 minutes before meals on an empty stomach.

Caution: Protease enzymes can irritate ulcers. Do not use if ulcers are present. If stomach burning or pain occurs, reduce dose or discontinue use.

Selected References

The Comprehensive Guide to Natures Sunshine Products by Tree of Light Publishing
Enzymes and Enzyme Therapy
by Anthony J. Cichoke
Food Enzymes
by Humbart Santillo
Enzyme Nutrition
by Edward Howell


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